PARP Inhibitor VI, NU1025 – CAS 90417-38-2 – Calbiochem

REF : 493800-5MG
Marca : Sigma-Aldrich
Descrição :PARP Inhibitor VI, NU1025 - CAS 90417-38-2 - Calbiochem The PARP Inhibitor VI, NU1025, also referenced under CAS 90417-38-2, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.
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Descrição detalhada : A potent inhibitor poly(ADP-ribose) polymerase (PARP; IC50 = 0.40 microM). Has been shown to potentiate the cytotoxicity of the DNA-methylating agent MTIC [5-(3-N-methyltriazen-1-yl)-imidazole-4-carboxamide] and ionizing irradiation in murine L210 leukemia cells., A potent poly(ADP-ribose) polymerase (PARP) inhibitor (IC50 = 400 nM) that potentiates the cytotoxicity of various DNA-active agents, including the DNA-methylating compound MTIC [5-(3-N-methyltriazen-1-yl)-imidazole-4-carboxamide], the DNA strand break-inducing drug temozolomide, topotecan, bleomycin, and ionizing radiation in murine L1210 leukemia cells, Chinese hamster ovary cells, and in a variety of human tumor cell lines.
Sinónimos : PARP Inhibitor VI, NU1025 - CAS 90417-38-2 - Calbiochem; 8-Hydroxy-2-methylquinazoline-4-one
Fórmula molecula r: C9H8N2O2
Armazenamento : -20C
Embalagem : 1X5MG