PARP Inhibitor XIV – CAS 1104546-89-5 – Calbiochem

REF : 528824-10MG
Marca : Sigma-Aldrich
Descrição :PARP Inhibitor XIV - CAS 1104546-89-5 - Calbiochem The PARP Inhibitor XIV, also referenced under CAS 1104546-89-5, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.
Clique para mais informações
Categoria :
CAS :
Descrição detalhada : A cell-permeable isoquinolinedione compound that potently inhibits PARP-1 activity (pIC50 = 7.35; IC50 = 45 nM) in a NAD+-competitive and reversible manner, while affecting PPAR-2 activity with a 100-fold lower potency. Selectively inhibits PARP-1-mediated cellular PAR formation and is of little effect against PAR formation in fibroblasts derived from parp-1(-/-) mice. Its in vivo application is limited by a poor aqueous solubility (~9 µM).
Sinónimos : PARP Inhibitor XIV - CAS 1104546-89-5 - Calbiochem; 4-(1-Methyl-1H-pyrrol-2-ylmethylene)-4H-isoquinoline-1,3-dione, BYK204165
Fórmula molecula r: C15H12N2O2
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X10MG