PD 168393 – CAS 194423-15-9 – Calbiochem

Descrição detalhada : A potent, cell-permeable, irreversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 700 pM). Does not inhibit other protein kinases. Acts by binding to the catalytic domain of the EGFR with a 1:1 stoichiometry and alkylating Cys773. Excellent antitumor agent in vivo., A potent, cell-permeable, irreversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 0.70 nM). Does not inhibit other protein kinases. Acts by binding to the catalytic domain of the EGFR with a 1:1 stoichiometry and alkylating Cys773. Excellent antitumor agent in vivo.
Sinónimos : PD 168393 - CAS 194423-15-9 - Calbiochem; 4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline
Fórmula molecula r: C17H13BrN4O
Armazenamento : -20C
Embalagem : 1X1MG