PDE4D Inhibitor, GEBR-7b – Calbiochem

Descrição detalhada : A cell permeable, potent, and selective oxime PDE4D inhibitor (IC50 = 0.67 µM) which displays much reduced activities toward other PDE4 isoforms. It is shown to cause a significant 40% increase in extracellular cAMP in the hippocampus of freely moving rats in vivo at 100 µM, but has no effect on Abeta levels. This compound elicits cognitive enhancement in vivo at the optimum dose of 0.003 mg/kg in both mice and rat models, and unlike rolipram, does not cause emesis-like behavior in rodents.
Sinónimos : PDE4D Inhibitor, GEBR-7b - Calbiochem; GEBR-7b, (E)-3-(cyclopentyloxy)-4-methoxybenzaldehyde, O-2-(2,6-dimethylmorpholino)-2-oxoethyl oxime
Fórmula molecula r: C21H30N2O5
Armazenamento : -20C
Embalagem : 1X5MG