Pepstatin A, Penetratin – Calbiochem

Descrição detalhada : A Pepstatin A (PepA; Cat. No. 516481) penetratin (pAntp43-58) conjugate (PepA-P) that is ~75% less potent against Cathespins D/E (IC50 = 920 nM) than PepA in cell-free assays, presumably due to its decreased solubility. However, with its enhanced permeability, PepA-P is much more active than PepA in inhibiting cellular aspartic protease activity in MCF7 (94.1% vs. 54.6% inhibition wtih 10 µM respective compound), Boleths, and Dendritic cultures. PepA-P, but not PepA, effectively interferes with antigen processing by primary APCs and the subsequent activation of antigen-specific memory T cells.
Sinónimos : Pepstatin A, Penetratin - Calbiochem; PepA-RQIKIWFQNRRMKWKK-OH, PepA-Antp????₈
Fórmula molecula r: C138H229N39O28S
Armazenamento : -20C
Embalagem : 1X1MG