Peroxiredoxin Inhibitor, Conoidin A – CAS 18080-67-6 – Calbiochem

Descrição detalhada : A cell-permeable dibromomethylquinoxaline-dioxide compound with nematicidal properties that covalently binds to the peroxidatic cysteine of peroxiredoxin II in Toxoplasma gondii (TgPrxII) and irreversibly blocks its hyperperoxidation activity (IC50 = 23 microM). Also shown to alkylate or crosslink catalytic cysteines of wild type AcePrx-1 in Ancylostoma ceylanicum and human PrxII and PrxIV to inhibit their catalytic activity with similar efficiency. Ineffective towards mitochondrial hPrxIII.Please note that the molecular weight for this compound is batch-specific due to variable water content., A cell-permeable dibromomethylquinoxaline-dioxide compound with nematicidal properties that covalently binds to the peroxidatic cysteine of peroxiredoxin II in Toxoplasma gondii (TgPrxII) and irreversibly blocks its hyperperoxidation activity (IC50 = 23 microM). Also shown to alkylate or crosslink catalytic cysteines of wild type AcePrx-1 in Ancylostoma ceylanicum and human PrxII and PrxIV to inhibit their catalytic activity with similar efficiency. Ineffective towards mitochondrial hPrxIII.
Sinónimos : Peroxiredoxin Inhibitor, Conoidin A - CAS 18080-67-6 - Calbiochem; 2,3- bis(Bromomethyl)quinoxaline-1,4-dioxide, Prx Inhibitor; 2,3-bis(Bromomethyl)quinoxaline-1,4-dioxide, Prx Inhibitor
Fórmula molecula r: C10H8Br2N2O2
Armazenamento : -20C
Embalagem : 1X1EA