PI-103 – CAS 371935-74-9 – Calbiochem

Descrição detalhada : A cell-permeable pyridinylfuranopyrimidine compound that acts as a potent and ATP-competitive inhibitor of DNA-PK, PI3-K, and mTOR (IC50 = 2, 8, 88, 48, 150, 26, 20, and 83 nM for DNA-PK, p110alpha, p110beta, p110delta, p110gamma, PI3-KC2beta, mTORC1, and mTORC2, respectively). It inhibits ATR and ATM only at much higher concentrations (IC50 = 850 and 920 nM, respectively) and exhibits little activity towards a panel of more than 40 other kinases even at concentrations as high as 10 µM. Shown to effectively block PI3-K/Akt signaling and cell proliferation in glioma cell lines both in vitro and in vivo. A 10 mM (2 mg/574 µl) solution of PI-103 (Cat. No. 528101) in DMSO is also available.
Sinónimos : PI-103 - CAS 371935-74-9 - Calbiochem; 3-(4-(4-Morpholinyl)pyrido[3?,2?:4,5]furo[3,2-d]pyrimidin-2-yl)phenol, mTOR Inhibitor V, PI 3-K Inhibitor V
Fórmula molecula r: C19H16N4O3
Armazenamento : -20C
Embalagem : 1X5MG