PI 3-Kalpha Inhibitor VIII – CAS 372196-77-5 – Calbiochem

Descrição detalhada : A cell-permeable imidazopyridine compound that acts as a highly potent and ATP-competitive DNA-PK and p110alpha-selective PI3-K inhibitor (IC50 = 0.3, 40, 100, and 850 nM for p110alpha, p110gamma, PI 3-K C2beta, and p110beta, respectively). Shown to effectively block cellular PI3-K/Akt signaling and inhibit tumor growth both in vitro (IC50 <=58 nM in MCF7, MCF7 ADR-res, HeLa, A375, and A549 cultures) and in mice in vivo (62% inhibition of HeLa xenograft in 2 weeks, 50 mg/kg/day, i.p.).
Sinónimos : PI 3-Kalpha Inhibitor VIII - CAS 372196-77-5 - Calbiochem; N-((1E)-(6-Bromoimidazo[1,2-a]pyridin-3-yl)methylene)-N?-methyl-N??-(2-methyl-5-nitrobenzene)sulfonohydrazide, HCl, PIK-75, PI 3-K Inhibitor VIII
Fórmula molecula r: C16H14BrN5O4S · 2H2O · xHCl
Armazenamento : 2-8C; 2-8C; 2-8C; 2-8C
Embalagem : 1X5MG