PI 3-Kgamma Inhibitor II – CAS 648449-76-7 – Calbiochem

Descrição detalhada : A cell-permeable thiazolidinedione compound that acts as a potent and ATP-competitive inhibitor of PI 3-Kgamma (Ki = 180 nM; IC50 = 250 nM). Exhibits great selectivity over PI 3-Kalpha (IC50 = 4.5 µM), PI 3-Kbeta and delta (IC50 >20 µM), and shows little effect towards a large panel of receptors, unrelated enzymes, ion channels, and 38 commonly studied kinases. Shown to block MCP-1-mediated monocyte chemotaxis in vitro and exhibit better in vivo efficacy than LY294002 (Cat. No. 440202 and 440204) in blocking RANTES- or thioglycollate-induced peritoneal neutrophil recruitment by oral administration in a murine peritonitis model.
Sinónimos : PI 3-Kgamma Inhibitor II - CAS 648449-76-7 - Calbiochem; 5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione, PI 3-K Inhibitor II
Fórmula molecula r: C11H5F2NO4S
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X5MG