Pifithrin-mu – CAS 64984-31-2 – Calbiochem

Descrição detalhada : A cell-permeable sulfonamide that blocks p53 interaction with Bcl-xL and Bcl-2 proteins and selectively inhibits p53 translocation to mitochondria without affecting the transactivation function of p53. Effectively protects against gamma radiation-induced cell death in vitro and animal lethality in vivo. Because Pifithrin-mu targets only the mitochondrial branch of the p53 pathway without affecting the important transcriptional functions of p53, it is superior to Pifithrin-alpha (Cat. No. 506132) in in vivo studies. Shown to selectively interact with inducible HSP70 and disrupt its functions.
Sinónimos : Pifithrin-mu - CAS 64984-31-2 - Calbiochem; Phenylacetylenylsulfonamide, Hsp70 Inhibitor I
Fórmula molecula r: C8H7NO2S
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X10MG