PknG Inhibitor – CAS 329221-38-7 – Calbiochem

REF : 370653-10MG
Marca : Sigma-Aldrich
Descrição :PknG Inhibitor - CAS 329221-38-7 - Calbiochem The PknG Inhibitor, also referenced under CAS 329221-38-7, controls the biological activity of PknG. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Clique para mais informações
Categoria :
CAS :
Descrição detalhada : A cell-permeable tetrahydrobenzothiophene compound that acts as a highly specific and ATP-binding site-targeting inhibitor against mycobacterial protein kinase G (PknG; IC50 = 390 nM), while exhibiting much reduced or no activity against 8 other mycobacterial and 25 other human kinases, including PKCalpha, the mammalian kinase most closely related to PknG. AX20017 is shown to completely inactivate PknG-mediated blockage of lysosomal transfer and degradation of M. bovis BCG in macrophages at concentrations (10µM or higher) that does not otherwise affect the growth of BCG outside its infected host.
Sinónimos : PknG Inhibitor - CAS 329221-38-7 - Calbiochem; Mycobacterial Protein Kinase G Inhibitor, 2-(Cyclopropanecarbonylamino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, AX20017
Fórmula molecula r: C13H16N2O2S
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X10MG