Proteasome Inhibitor I – Calbiochem

REF : 539160-5MG
Marca : Sigma-Aldrich
Descrição :Proteasome Inhibitor I - Calbiochem The Proteasome Inhibitor I controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
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Descrição detalhada : A cell-permeable, reversible inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (MCP; 20S proteasome) in HT4 cells. Causes the accumulation of ubiquitinated proteins in neuronal cells. Prevents the activation of NF-kappaB in response to TNF-alpha and Okadaic Acid (Cat. No. 495604) through inhibition of IkappaB-alpha degradation. A 50 mM (5 mg/162 µl) solution of Proteasome Inhibitor I (Cat. No. 539161) in DMSO is also available., Cell-permeable inhibitor of the chymotrypsin-like activity of the multicatalytic proteinase complex (MCP; 20S proteasome) in HT4 cells. Causes the accumulation of ubiquitinylated proteins in neuronal cells. Prevents NF-kappaB activation in response to TNFalpha and okadaic acid through inhibition of IkappaB-alpha degradation, thereby interfering with induction of iNOS in macrophages.
Sinónimos : Proteasome Inhibitor I - Calbiochem; PSI
Fórmula molecula r: C32H50N4O8
Armazenamento : -20C
Embalagem : 1X5MG