Raf Kinase Inhibitor IV – CAS 303727-31-3 – Calbiochem

REF : 553014-1MG
Marca : Sigma-Aldrich
Descrição :Raf Kinase Inhibitor IV - CAS 303727-31-3 - Calbiochem The Raf Kinase Inhibitor IV, also referenced under CAS 303727-31-3, controls the biological activity of Raf Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
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Descrição detalhada : A cell-permeable triarylimidazole compound that acts as a reversible, ATP-competitive, and highly potent inhibitor of Raf kinase (IC50 = 10 nM & Kd = 2.4 nM for B-raf) with 7-, 30-, and 70-fold selectivity over p38alpha, GSK-3beta, and Lck, respectively. Cellular data have indicated that the compound is more effective towards Raf-1and A-Raf than B-Raf., A cell-permeable triarylimidazole compound that acts as a reversible, ATP-competitive, and highly potent inhibitor of Raf kinase (IC50 = 10 nM and Kd = 2.4 nM for B-raf) with 7-, 30-, and 70-fold selectivity over p38alpha, GSK-3beta, and Lck, respectively. Cellular data have indicated that the compound is more effective towards Raf-1and A-Raf than B-Raf.
Sinónimos : Raf Kinase Inhibitor IV - CAS 303727-31-3 - Calbiochem; 2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole, L 779450
Fórmula molecula r: C20H14ClN3O
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X1MG