Ras/Rac Transformation Blocker, SCH 51344 – CAS 171927-40-5 – Calbiochem
REF : 553509-10MG
Marca : Sigma-Aldrich
Descrição :Ras/Rac Transformation Blocker, SCH 51344 - CAS 171927-40-5 - Calbiochem A cell-permeable pyrazoloquinoline compound that acts as an effective blocker of Ras-induced malignant transformation and inhibits Ras/Rac-dependent dissociation of EMS1 from the actin-myosin II complex and membrane ruffling.
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Categoria : Small Molecules
Descrição detalhada : A cell-permeable pyrazoloquinoline compound that acts as an effective blocker of Ras-induced malignant transformation and inhibits Ras/Rac-dependent dissociation of EMS1 from the actin-myosin II complex and membrane ruffling. The effect of SCH 51344 is limited to Ras/Rac pathway(s) other than those involving ERK and JNK. Shown to directly target human mutT homolog MTH1/NUDT1 with a Kd of 49 nM and inhibit its catalytic activity (IC50 for pyrophosphate release during nucleotide triphosphate hydrolysis = 215, 410 and 675 nM against dGTP, 8-oxo-dGTP and 2-OH-dATP substrates, respectively).
Sinónimos : Ras/Rac Transformation Blocker, SCH 51344 - CAS 171927-40-5 - Calbiochem; 6-Methoxy-4-(2-((2-hydroxyethoxyl)-ethyl)amino)-3-methyl-1H-pyrazolo[3,4-b]quinoline
Fórmula molecula r: C16H20N4O3
Armazenamento : -20C
Embalagem : 1X10MG
Sinónimos : Ras/Rac Transformation Blocker, SCH 51344 - CAS 171927-40-5 - Calbiochem; 6-Methoxy-4-(2-((2-hydroxyethoxyl)-ethyl)amino)-3-methyl-1H-pyrazolo[3,4-b]quinoline
Fórmula molecula r: C16H20N4O3
Armazenamento : -20C
Embalagem : 1X10MG