Ro-31-8425 – CAS 131848-97-0 – Calbiochem

Descrição detalhada : A potent, cell-permeable, reversible, ATP-competitive, and selective protein kinase C inhibitor (IC50 = 15 nM for rat brain PKC). Exhibits some degree of isozyme specificity (IC50 = 8 nM for PKCalpha, 8 nM for PKCbetaI, 14 nM for PKCbetaII, 13 nM for PKCgamma, and 39 nM for PKCepsilon). Upregulates CD11a expression and enhances mesenchymal stromal cell adhesion under flow., A potent, cell-permeable, reversible, ATP-competitive, and selective protein kinase C inhibitor (IC50 = 15 nM for rat brain PKC). Exhibits some degree of isozyme specificity (IC50 = 8 nM for PKCalpha, 8 nM for PKCbetaI, 14 nM for PKCbetaII, 13 nM for PKCgamma, and 39 nM for PKCepsilon). Shows slight selectivity for the conventional PKC isozymes PKCalpha, PKCbeta, and PKCgamma over the Ca2+-independent PKC isozyme PKCepsilon. Upregulates CD11a expression and enhances mesenchymal stromal cell adhesion under flow.
Sinónimos : Ro-31-8425 - CAS 131848-97-0 - Calbiochem; 2-[8-(Aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-3-yl]-3-(1-methyl-1H-indol-3-yl)maleimide, HCl, Bisindolylmaleimide X, HCl
Fórmula molecula r: C26H24N4O2 · xHCl
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X1MG