SB 225002 – CAS 182498-32-4 – Calbiochem

Descrição detalhada : A potent and selective antagonist of G-protein coupled receptor CXCR2 (IL-8RB; IC50 = 22 nM for the inhibition of 125I-IL-8 binding to CXCR2). Inhibits human and rabbit neutrophil chemotaxis induced by both IL-8 and GROalpha in vitro and selectively blocks IL-8-induced neutrophil margination in rabbits. Reduces presenilin expression, inhibits gamma-secretase activity, and blocks Abeta40/42 production and notch processing; further, demonstrates in vivo efficacy in mouse models., A potent, selective, and competitive antagonist of the G-protein coupled receptor CXCR2 (IL-8RB; IC50 = 22 nM for the inhibition of 125I-IL-8 binding to CXCR2). Shows ~150-fold selectivity over CXCR1. Inhibits human and rabbit neutrophil chemotaxis induced by both IL-8 and GROalpha in vitro and in vivo selectively blocks IL-8-induced neutrophil margination in rabbits. Reduces presenilin expression, inhibits gamma-secretase activity, and blocks Abeta40/42 production and notch processing; further, demonstrates in vivo efficacy in mouse models.
Sinónimos : SB 225002 - CAS 182498-32-4 - Calbiochem; N-(2-Hydroxy-4-nitrophenyl)-N?-(2-bromophenyl)urea, CXCR2 Antagonist II
Fórmula molecula r: C13H10BrN3O4
Armazenamento : -20C
Embalagem : 1X1MG