SB-269970 Hydrochloride – CAS 261901-57-9 – Calbiochem

Descrição detalhada : A selective 5-HT7 receptor antagonist. Extremely potent in vivo and in vitro. Chronic or acute (even single dose) administration of SB269970 induces functional desensitization of the 5-HT7 receptor system, which precedes changes in the receptor density. This mechanism may be responsible for the rapid antidepressant-like effect of the 5-HT7 antagonist in animal models. SB-269970 is an analogue of SB-258719 and has been shown to have at least 100 fold selectivity versus all other 5-HT receptor subtypes except the human 5-HT5A receptor (pKi values are 8.9, 7.2 and 6.0 for 5-HT7A, 5-HT5A and 5-HT1B).
Sinónimos : SB-269970 Hydrochloride - CAS 261901-57-9 - Calbiochem; 5-HT7 Serotonin receptor antagonist, SB-269970, SB 26,970, SB 26,970
Fórmula molecula r: C18H28N2O3S · xHCl
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X1EA