SecinH3 – CAS 853625-60-2 – Calbiochem

Descrição detalhada : A cell-permeable triazolo compound that acts as a Sec7 domain-binding (Kd <=250 nM for Sec7 from human cytohesins 1-3), selective antagonist against cytohesin family small GEFs (IC50 <=5.6 µM in ARF1 GDP/GTP exchange assays using human cytohesin 3, as well as murine and Drosophila homologues). It inhibits large GEFs only at much higher concentrations (IC50 >=65 µM in GDP/GTP exchange assays using hEFA6-S7 and yGea2-S7) and exhibits little activity against a panel of 10 commonly studied kinases or hSosII. Shown to effectively inhibit insulin signaling both in HepG2 cells in vitro and in Drosophila and mice in vivo.
Sinónimos : SecinH3 - CAS 853625-60-2 - Calbiochem; N-(4-(5-(1,3-Benzodioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl)phenyl)-2-(phenylthio)acetamide, Cytohesin Inhibitor I
Fórmula molecula r: C24H20N4O4S
Armazenamento : 2-8C; 2-8C
Embalagem : 1X5MG