SHIP2 Inhibitor II, CPDA – Calbiochem

Descrição detalhada : A cell-permeable aminopyridine acetamide based compound that acts as an inhibitor of SH2 domain-containing inositol 5'-phosphatase 2 (SHIP2) that can overcome insulin resistance in 3T3-L1 adipocytes. Enhances insulin-stimulated Akt phosphorylation (Thr308) in TNFa-treated 3T3-L1 adipocytes (~10 µM) and in primary cultured neurons from rat cerebral cortex. Improves glucose tolerance in db/db mice (~300 mg/kg b.i.d) without affecting their fasting glucose levels. Also reduces the expression levels of glucose-6-phosphatase and phosphoenolpyruvate carboxykinase.
Sinónimos : SHIP2 Inhibitor II, CPDA - Calbiochem
Fórmula molecula r: C20H15ClF2N2O2
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X1EA