SHP1/2 PTPase Inhibitor, NSC-87877 – CAS 56932-43-5 – Calbiochem

REF : 565851-50MG
Marca : Sigma-Aldrich
Descrição :SHP1/2 PTPase Inhibitor, NSC-87877 - CAS 56932-43-5 - Calbiochem The SHP1/2 PTPase Inhibitor, NSC-87877, also referenced under CAS 56932-43-5, controls the biological activity of SHP1/2 PTPase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
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Descrição detalhada : A cell-permeable 7-aza-8-hydroxyquinoline compound that acts as a potent, catalytic site-targeting inhibitor of SHP-1 and SHP-2 protein tyrosine phosphatases (IC50 = 355 nM and 318 nM, respectively). It inhibits PTP1B and HePTP with less potency (IC50 = 1.69 µM and 7.75 µM, respectively) and exhibits >200-fold selectivity over DEP1, CD45, and LAR. Shown to inhibit both basal and stimulated SHP-2 activity in HEK293 cells.
Sinónimos : SHP1/2 PTPase Inhibitor, NSC-87877 - CAS 56932-43-5 - Calbiochem; 8-Hydroxy-7-(6-sulfonaphthalen-2-yl)diazenyl-quinoline-5-sulfonic acid, Disodium Salt, HePTP Inhibitor II, PTP Inhibitor XXV, PTP1B Inhibitor IV, SHP1 Inhibitor I, SHP2 Inhibitor I
Fórmula molecula r: C19H11N3Na2O7S2
Armazenamento : 2-8C; 2-8C; 2-8C; 2-8C
Embalagem : 1X50MG