SIRT2 Inhibitor, AGK2 – CAS 304896-28-4 – Calbiochem

REF : 566324-5MG
Marca : Sigma-Aldrich
Descrição :SIRT2 Inhibitor, AGK2 - CAS 304896-28-4 - Calbiochem The SIRT2 Inhibitor, AGK2, also referenced under CAS 304896-28-4, controls the biological activity of SIRT2. This small molecule/inhibitor is primarily used for Cell Structure applications.
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Descrição detalhada : A cell-permeable quinoline compound that targets the nicotinamide-binding site and acts as a reversible sirtuin 2- (SIRT2) selective inhibitor (IC50 = 3.5 µM) with little activity against SIRT1/3 (IC50 >50 µM). Prevents cellular alpha-tubulin deacetylation in HeLa cells in a dose-dependent manner and with little cytotoxic effect. Shown to rescue alpha-Synuclein-mediated toxicity both in primary rat embryo midbrain cultures in vitro and in a Drosophila PD model in vivo. The inactive isomer AGK7 (Cat. No. 566326) can be used as a negative control.
Sinónimos : SIRT2 Inhibitor, AGK2 - CAS 304896-28-4 - Calbiochem; 2-Cyano-3-(5-(2,5-dichlorophenyl)-2-furanyl)-N-5-quinolinyl-2-propenamide, Sirtuin 2 Inhibitor, SIRT2 Inhibitor I, SIRT1 Inhibitor IV
Fórmula molecula r: C23H13Cl2N3O2
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X5MG