Sodium 4-Phenylbutyrate – CAS 1716-12-7 – Calbiochem

Descrição detalhada : A novel anti-neoplastic agent and transcriptional regulator. Also acts as an inducer of tumor cytostasis and differentiation. Increases fetal hemoglobin production in vitro and in vivo., An antineoplastic agent that demonstrates potent differentiating capacity in multiple hematopoietic and solid tumor cell lines. Acts as an inducer of tumor cytostasis and differentiation as well as of peroxisomal proliferation. A more effective inhibitor of histone deacetylase and inducer of histone acetylation than its structural analogs including 2- and 3-phenylbutyrate. Acts as a transcriptional regulator and improve the targeting of deltaF508-CFTR (cystic fibrosis transmembrane regulator) for ubiquitination and degradation by reducing the expression of HSC70 in epithelial cells. Also, reported to increase fetal hemoglobin production in vitro and in vivo.
Sinónimos : Sodium 4-Phenylbutyrate - CAS 1716-12-7 - Calbiochem; SPB, PBNa, 4PBA, 4-Phenylbutyrate, Na, BCKD Kinase Inhibitor I, Branched-Chain alpha-Ketoacid Dehydrogenase Kinase Inhibitor I, BDK Inhibitor I
Fórmula molecula r: C10H11NaO2
Armazenamento : -20C
Embalagem : 1X100MG