Sodium Stibogluconate – CAS 16037-91-5 – Calbiochem

Descrição detalhada : A pentavalent antimony compound that forms a stable complex with and irreversibly inhibits Src homology protein tyrosine phosphatase (SHP-1) (99% inhibition at 11 µM). Also inhibits SHP-2 and PTP1B at an ~10-fold higher concentration (~110 µM). Does not inhibit the dual specificity protein tyrosine phosphatase (PTPase) or mitogen-activated protein kinase phosphatase-1 (MKP-1). Reported to induce general protein tyrosine phosphorylation and enhance IL-3-induced protein tyrosine phosphorylation of Jak2 and Stat5 in Baf3 cells. Also reported to augment IL-3-induced proliferation in Baf3 cells (ECmax = 44 µM) and GM-CSF-induced proliferation in TF-1 cells (ECmax = 55 µM). Exhibits anti-leishmanial effects., A pentavalent antimony compound that irreversibly inhibits protein tyrosine phosphatase (PTPase) activity, including Src homology PTPase-1 (SHP-1) (99% inhibition at ~11 µM) by forming a stable complex. At higher concentrations (~110 µM), it inhibits SHP-2 and PTP1B activities.
Sinónimos : Sodium Stibogluconate - CAS 16037-91-5 - Calbiochem; SSG, Antimony Sodium Gluconate, NaSbv, PTP Inhibitor XXIV, SHP1 Inhibitor IV
Fórmula molecula r: C12H17O17Sb2 · 3Na · 9H2O
Armazenamento : 2-8C; 2-8C; 2-8C; 2-8C
Embalagem : 1X1GM