SPARC/Osteonectin human

Descrição detalhada : SPARC (secreted protein acidic and cysteine rich) is a multifunctional Ca2+-binding glycoprotein that belongs to the matricellular protein family, and is one of the eight members of the SPARC family. In adult animals, SPARC protein is generally expressed in remodeling tissues, such as bone, mucosa of the gut, and healing wounds. It shows predominant expression in tumors and in disorders linked with fibrosis. It is composed of three domains, which include a novel follistatin-like module, the acidic N-terminal (NT) domain and an extracellular calcium-binding EC module containing two EF-hand motifs. It is also known as osteonectin, and has a molecular weight of 32kDa. The gene is localized to human chromosome 5q33.1, and the encoded protein is a single polypeptide composed of 285 amino acids.
Sinónimos : BM-40; ON; Secreted protein acidic and rich in cysteine
Armazenamento : -20C
Embalagem : 1X50UG