Splitomicin – CAS 5690-03-9 – Calbiochem

Descrição detalhada : A cell-permeable lactone derived from beta-naphthol that acts as a selective inhibitor of NAD+-dependent histone deacetylase activity of Sir2 protein (IC50 = 60 µM). It creates a conditional phenocopy of a sir2 deletion mutant in S. cerevisiae and sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket., A cell-permeable and selective inhibitor of NAD+-dependent deacetylase activity of Sir2 protein (IC50 = 60 µM). Creates a phenocopy of the sir2 deletion mutant in S. cerevisiae and sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Reported to act by either altering or blocking access to the acetylated histone-binding pocket.
Sinónimos : Splitomicin - CAS 5690-03-9 - Calbiochem; 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one
Fórmula molecula r: C13H10O2
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X5MG