(S,R,S)-AHPC-PEG2-butyl amine hydrochloride

Descrição detalhada : Protein degrader builiding block (S,R,S)-AHPC-PEG2-butyl amine (HCl salt) enables the synthesis of molecules for targeted protein degradationand PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
Sinónimos : (2S,4R)-1-((S)-2-(2-(2-((6-Aminohexyl)oxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide; (S,R,S)-AHPC-2-2-6-NH2 HCl salt; Crosslinker-E3 ligase ligand conjugate; Protein degrader building block for PROTAC(R) research; Template for synthesis of targeted protein degrader; VH032 conjugate
Fórmula molecula r: C32H49N5O6S · xHCl
Armazenamento : 2-8C
Embalagem : 1X50MG