TAPI-2 – CAS 187034-31-7 – Calbiochem

Descrição detalhada : A hydroxamate-based inhibitor of matrix metalloproteinases and TACE (TNF-alpha convertase; ADAM17). Inhibits the activation-dependent shedding of L-selectin from neutrophils, eosinophils, and lymphocytes as well as phenylarsine oxide (PAO)-induced shedding in neutrophils. Also blocks the shedding of several cell surface proteins such as pro-TGF-alpha, IL-6 receptor alpha-subunit, and beta-amyloid precursor protein. Reported to inhibit TNF-alpha release and impart protection against aspirin-induced gastric mucosal injury. Acts as a weak inhibitor of angiotensin converting enzyme (IC50 = 18 µM)., A hydroxamate-based inhibitor of MMPs and TACE. Inhibits the activation-induced shedding of L-selectin from neutrophils, eosinophils, and lymphocytes, as well as phenylarsine oxide (PAO)-induced shedding in neutrophils. Also acts as a weak inhibitor of angiotensin converting enzyme (IC50 = 18 µM). Also available as a 10 mM solution in H2O (Cat. No. 509612).
Sinónimos : TAPI-2 - CAS 187034-31-7 - Calbiochem; N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L- t-butyl-alanyl-L-alanine, 2-aminoethyl Amide, TNF-alpha Protease Inhibitor-2; N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-t-butyl-alanyl-L-alanine, 2-aminoethyl Amide, TNF-alpha Protease Inhibitor-2
Fórmula molecula r: C19H37N5O5
Armazenamento : -20C
Embalagem : 1X1MG