TCPOBOP – CAS 76150-91-9 – Calbiochem

Descrição detalhada : A highly potent inducer of phenobarbital-like class of cytochrome P450 (CYP) enzymes. A tumor promoter that induces hepatocyte proliferation, independent of the presence of cytokines or transcription factors. Activates orphan nuclear receptors mCAR (mouse constitutive androstane receptor) and hPXR (human pregane X receptor), but has little or no effect on hCAR and mPXR. Also suppresses the expression of multi-drug resistance genes mdr2 and mdr3 in mouse liver., The most potent known member of the phenobarbital-like class of cytochrome P450 (CYP)-inducing agents. Acts as a tumor promoter of murine hepatocarcinogenesis; activates orphan nuclear receptors mCAR (mouse Constitutive Androstane Receptor) and hPXR (human Pregnane X Receptor), but has little or no activity on hCAR and mPXR. Also suppresses the multidrug resistance gene expression in the mouse liver.
Sinónimos : TCPOBOP - CAS 76150-91-9 - Calbiochem; 1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene
Fórmula molecula r: C16H8Cl4N2O2
Armazenamento : -20C
Embalagem : 1X25MG