TIRAP Inhibitor Peptide, Cell-Permeable – Calbiochem

REF : 613570-1MG
Marca : Sigma-Aldrich
Descrição :TIRAP Inhibitor Peptide, Cell-Permeable - Calbiochem The TIRAP Inhibitor Peptide, Cell-Permeable blocks LPS-, but not CpG-induced NF-kappaB activation. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
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Descrição detalhada : A synthetic, cell-permeable peptide that corresponds to mouse toll-interleukin 1 receptor (TIR) domain-containing adapter protein 138-151 (TIRAP; also called Mal (MyD88-adapter-like), fused to the Drosophila antennapedia sequence. Shown to specifically inhibit LPS-induced, but not CpG-induced, NF-kappaB activation, PKR phosphorylation, and JNK phosphorylation in RAW.kappaB cells at ~40 µM. Also reported to block IkappaBalpha degradation., A cell-permeable synthetic peptide containing mouse TIRAP138-151 fused to the Drosophila Antennapedia sequence. Specifically inhibits LPS-, but not CpG-induced NF-kappaB activation, PKR phosphorylation, and JNK phosphorylation in RAW.kappaB cells at ~40 µM. Also reported to block IkappaBalpha degradation.
Sinónimos : TIRAP Inhibitor Peptide, Cell-Permeable - Calbiochem; Mal Peptide, MyD88-Adapter-Like Peptide, Toll-interleukin 1 Receptor (TIR) domain-containing Adapter Protein Peptide, Ant-Tirap 138-151, TIRAP Peptide, (RQIKIWFNRRMKWKKLQLRDAAPGGAIVS)
Fórmula molecula r: C163H268N52O38S
Armazenamento : -20C
Embalagem : 1X1MG