TNF-alpha Antagonist III, R-7050 – CAS 303997-35-5 – Calbiochem

Descrição detalhada : A cell-permeable triazoloquinoxaline compound that acts as a TNF-alpha receptor antagonist via the blockage of receptor-adaptor molecules complex formation and subsequent receptor internalization, but not TNF-alpha ligand-receptor binding. Shown to selectively inhibit TNF-alpha-, but not Fas- or C6-ceramide-, induced caspase activation and cell death in ME180 cells and exhibit higher potency against TNF-alpha-induced than IL-1beta-induced NF-kappaB activation (EC50 = 0.631 and 1.45 µM, respectively) in A549 cells.
Sinónimos : TNF-alpha Antagonist III, R-7050 - CAS 303997-35-5 - Calbiochem; 8-Chloro-4-(phenylsulfanyl)-1-(trifluoromethyl)[1,2,4]triazolo[4,3-a]quinoxaline
Fórmula molecula r: C16H8ClF3N4S
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X10MG