Topoisomerase II Inhibitor, BNS-22 – Calbiochem

Descrição detalhada : A potent, 2H-chromen-2-one small molecule inhibitor that is selective for TOP2 (IC50 = 2.8 µM and 0.42 µM for TOP2alpha and TOP2beta, respectively). Unlike TOP2 poisons such as etoposide, it does not lead to DNA damage associated with DNA Double-Strand Breaks, as evidenced by the lack of gamma-H2AX accumulation but instead inhibits kinetoplast DNA decatenation in vitro. This compound affects cell cycle at the M phase and disturbs mitotic spindle formation in HeLa cells at 3-10 µM. It also exhibits significant anti-proliferative activities against several human cancer cell lines.
Sinónimos : Topoisomerase II Inhibitor, BNS-22 - Calbiochem; BNS-22
Fórmula molecula r: C24H25NO5
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X10MG