Triptolide, Tripterygium wilfordii – CAS 38748-32-2 – Calbiochem

Descrição detalhada : A novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent. Induces apoptosis in tumor cells, sensitizes tumor cells to TNF-alpha-induced activation of NF-kappaB. Also inhibits IL-2 expression in activated T-cells at the level of purine-box/nuclear factor and NF-kappaB transcriptional activation. Also reported to inhibit mitogen activated protein kinase phosphatase-1 (MKP-1). Reported to induce apoptosis by activating DEVD-cleaving caspases., A novel diterpene triepoxide isolated from the Chinese herb Tripterygium wilfordii that acts as a potent immunosuppressant and anti-inflammatory agent. Induces apoptosis in tumor cells by activating DEVD-cleaving caspases. Sensitizes tumor cells to TNF-alpha-induced apoptosis, and inhibits TNF-alpha-induced activation of NF-kappaB. Also inhibits T cell IL-2 expression at the level of purine-box/nuclear factor of activated T cells and NF-kappaB transcriptional activation. Also reported to inhibit mitogen activated protein kinase phosphatase-1 (MKP-1).
Sinónimos : Triptolide, Tripterygium wilfordii - CAS 38748-32-2 - Calbiochem; PG490
Fórmula molecula r: C20H24O6
Armazenamento : -20C
Embalagem : 1X5MG