TrkB Antagonist, ANA-12 – CAS 219766-25-3 – Calbiochem

Descrição detalhada : A cell-permeable thiophene carboxymide derived compound that acts as a direct and selective antagonist of TrkB receptor. Binds to the high affinity site on the extracellular domain of TrkB in a dose-dependent manner (Kd = 10 nM) exhibiting much reduced binding to the low affinity site (Kd =12 µM) indicating that it does not compete with BDNF for the same binding site. Does not affect TrkA or TrkC receptors. Shown to permeate the blood-brain barrier, however, its antagonistic effects are not uniform throughout the brain. Does not affect the survivability of neurons. Reduces anxiety and depression related behavior in mice.
Sinónimos : TrkB Antagonist, ANA-12 - CAS 219766-25-3 - Calbiochem; N-(2-((2-oxoazepan-3-yl)carbamoyl)phenyl)benzo[b]thiophene-2-carboxamide
Fórmula molecula r: C22H21N3O3S
Armazenamento : 2-8C; 2-8C
Embalagem : 1X1EA