TRPC3 Channel Inhibitor, Pyr3 – CAS 1160514-60-2 – Calbiochem

REF : 648490-10MG
Marca : Sigma-Aldrich
Descrição :TRPC3 Channel Inhibitor, Pyr3 - CAS 1160514-60-2 - Calbiochem The TRPC3 Channel Inhibitor, Pyr3, also referenced under CAS 1160514-60-2, controls the biological activity of TRPC3 Channel. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
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Descrição detalhada : A cell-permeable pyrazole that acts as an equally potent blocker of Stim1 and Orai1-coupled CRAC (Ca2+ release-activated Ca2+) channel-mediated SOCE (store-operated Ca2+ entry) in RBL-2H3 cells (IC50 = 540 nM by Fura-2; peak current density pA/pF = -1.45 and -7.50, respectively, with or without 3 µM BTP2/Pyr3 by whole cell clamp) and the transient receptor potential cation channel TRPC3-mediated ROCE (receptor-operated Ca2+ entry) in TRPC3-expressing HEK293 cells (IC50 = 540 nM; by Fura-2; pA/pF = -2.27 and -18.50, respectively, with or without 3 µM BTP2/Pyr3). Pyr3 is also demonstrated to alleviate pressure overload-induced cardiac hypertrophy following TAC (transverse aortic constriction) operation in mice (0.1 mg/kg/day via i.p. osmotic pump) in vivo. A great complement to Pyr 2 (Cat. No. 203890), Pyr6, and Pyr10 in Ca2+ signaling studies.
Sinónimos : TRPC3 Channel Inhibitor, Pyr3 - CAS 1160514-60-2 - Calbiochem; Ethyl-1-(4-(2,3,3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate, SB-360475, CRAC Channel Inhibitor II
Fórmula molecula r: C16H11Cl3F3N3O3
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X10MG