UCH-L1 Inhibitor – CAS 668467-91-2 – Calbiochem

Descrição detalhada : A potent, reversible, competitive, and active site-directed inhibitor of ubiquitin C-terminal hydrolase L1 (UCH-L1) (Ki = 400 nM; IC50 = 880 nM). Exhibits ~28-fold greater selectivity for UCH-L1 compared to UCH-L3 (Cat. No. 662090). Shown to increase proliferation of the UCH-L1-expressing tumor cell line, SH-SY5Y, at a concentration of 5 µM. Useful tool for studying the roles of UCH-L1 in cancer, Parkinson's disease, and other neurological disorders. Cell-permeability is reported to vary from cell type to cell type., An isatin O-acyl oxime compound that acts as a potent, reversible, competitive, and active site-directed inhibitor of UCH-L1 (Ki = 0.40 µM; IC50 = 0.88 µM) with ~28-fold greater selectivity over UCH-L3 (Cat. No. 662090). Shown to increase proliferation of UCH-L1 expresssing tumor cell line SH-SY5Y at 5 µM. A useful tool for studying the roles of UCH-L1 in cancer, Parkinson's disease, and other neurological disorders. Permeability may vary from cell type to cell type.
Sinónimos : UCH-L1 Inhibitor - CAS 668467-91-2 - Calbiochem; LDN-57444, Ubiquitin C-Terminal Hydrolase L1 Inhibitor, Ubiquitin C-Terminal Esterase L1 Inhibitor, Ubiquitin Thiolesterase L1 Inhibitor
Fórmula molecula r: C17H11Cl3N2O3
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X10MG