UCN-01

Descrição detalhada : A cell-permeable Staurosporine (Cat. No. 569397) derived anticancer agent that reversibly and ATP-competitively inhibits several protein kinases (IC50 = 29 nM, 34 nM, 30 nM, 590 nM and 530 nM for PKCalpha, PKCbeta, PKCgamma, PKCdelta and PKCepsilon; IC50 = 7 nM, 27 nM, 50 nM, 50 nM, 150 nM and 1.04 M for Chk1, Cdc25C-associated protein kinase 1, Cdk1, PAK4, Cdk5/p25 and Chk2; IC50 = 33 nM, 50 nM, 95 nM, 500 nM, 500 nM and 1.0 M for PDK1, lck, MAPKAP kinase-2, Akt, GSK-3beta and PKA, respectively). At higher concentrations (>15 M), affects the activities of Src, PIM-1, CKII, DNA-PK, ErK1, ILK-1 and MAPKK1). Reported to suppress thymidylate synthase expression, induce apoptosis with caspase activation, and sensitize tumor cells to a range of DNA-damaging agents.
Sinónimos : UCN-01; 7-Hydroxystaurosporine, Staurosporine, 7beta-Hydroxy, Streptomyces sp., Chk1 Inhibitor VI, Chk2 Inhibitor V; 7-Hydroxystaurosporine, Staurosporine, 7beta-Hydroxy, Streptomyces sp., Chk1 Inhibitor VI, Chk2 Inhibitor V
Fórmula molecula r: C28H26N4O4
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X500UG