UFH-001 Human Breast Cancer Cell Line

Descrição detalhada : The UFH-001 triple negative CAIX+ human breast cancer cell line constitutively expresses CAIX under both hypoxic and normoxic conditions, exhibits an aggressive TNBC phenotype in vivo, and supports tumor growth in a mouse xenograft model . The constitutive expression of CAIX in UFH-001 cells facilitates its evaluation as a potential therapeutic target both in vitro and in vivo. Source:UFH-001 cells are derived from MCF-10A cells, a spontaneously immortalized breast cancer epithelial cell line originating from breast tissue of a healthy female patient . UFH-001 cells were sorted for CAIX expression by flow cytometry ., Triple negative breast cancer (TNBC) accounts for 15-20% of breast cancer cases and is characterized by the absence of estrogen receptor (ER), progesterone receptor (PR), and human EGF receptor 2 (HER2) . TNBC is typically more aggressive and difficult to treat than more common types of breast cancer and is more likely to recur after treatment. Carbonic anhydrase IX (CAIX) catalyzes the reversible hydration of carbon dioxide and is a marker for hypoxic regions of breast tumors. CAIX expression is associated with poor prognosis in TNBC and hormone-resistant breast tumors.
Sinónimos : CAIX-positive breast cancer cells; triple negative breast cancer cells
Armazenamento : -140C Degree Freezer
Embalagem : 1X1EA