Ursolic Acid – CAS 77-52-1 – Calbiochem

Descrição detalhada : A cell-permeable plant-derived pentacyclic triterpene acid that displays anti-inflammatory, immunomodulatory, and antitumor activities. Shown to inhibit the phosphatase activity of SHP2, PTP1B, and TCPTP (IC50 = 2.73, 3.08 and 3.33 µM, respectively) as well as induce IR autophosphorylation independent of its phosphatase inhibitory activity. Ursolic acid is also reported to inhibit NF-kappaB and STAT3 pathway activation in cancer cultures, resulting in enhanced sensitivity to chemotherapy agents and apoptotic cell death.
Sinónimos : Ursolic Acid - CAS 77-52-1 - Calbiochem; 3beta-Hydroxy-urs-12-en-28-oic acid, CG7, PTP1B Inhibitor VII, PTP Inhibitor XXVII, PTPN2/TCPTP Inhibitor II, SHP2 Inhibitor IV; 3beta-Hydroxy-urs-12-en-28-oic acid, CG7, PTPN2/TCPTP Inhibitor II, SHP2 Inhibitor IV, PTP1B Inhibitor VII, PTP Inhibitor XXVII
Fórmula molecula r: C30H48O3
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X50MG