VEGFR2 Kinase Inhibitor VI, Ki8751 – CAS 228559-41-9 – Calbiochem

Descrição detalhada : A cell-permeable quinolyloxyphenyl-urea compound that acts as a VEGFR-2-selective inhibitior in both cell-based (IC50 = 0.9 nM in VEGF-induced receptor phosphorylation) and cell-free (IC50 = 4.0 nM in kinase reactions) assays. It inhibits c-Kit, PDGFRalpha, and FGFR-2 only at much higher concentrations (IC50 = 40, 67, and 170 nM, respectively, in cell-based assays), while exhibiting no effect against eight other commonly studied receptor and non-receptor kinases even at concentrations as high as 10 µM. Effectively blocks VEGF-dependent, but not VEGF-independent, cell proliferation in vitro and tumor growth in mice and rats (5 to 20 mg/kg, daily p.o.) in vivo.
Sinónimos : VEGFR2 Kinase Inhibitor VI, Ki8751 - CAS 228559-41-9 - Calbiochem; N-(2,4-Difluorophenyl)-N?-(4-(6,7-dimethoxy-4-quinolyloxy)-2-fluorophenyl)urea, Vascular Endothelial Growth Factor Receptor 2 Kinase Inhibitor VI, VEGFR Tyrosine Kinase Inhibitor XXIV
Fórmula molecula r: C24H18F3N3O4
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X5MG