Withaferin A, Withania somnifera – CAS 5119-48-2 – Calbiochem

Descrição detalhada : A cell-permeable steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties. Potently inhibits angiogenesis both in vitro (IC50 = 12 nM against HUVEC proliferation) and in vivo (80% inhibition at 7 µg/kg/day in C57BL/6J mice, s.c.) and NF-kappaB activation (IC50 = 500 nM in TNF-alpha-induced endothelial cells) by targeting the ubiquitin-mediated proteasome pathway. At higher concentrations (~5 µM) also affects AP-1 transcription and induces cell death.
Sinónimos : Withaferin A, Withania somnifera - CAS 5119-48-2 - Calbiochem
Fórmula molecula r: C28H38O6
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X5MG