WT-1 Mouse Brown Preadipocyte Cell Line

Descrição detalhada : Obesity is a growing worldwide health epidemic that has spurred research into new avenues for treatment and control of metabolic disorders. Brown fat, a specialized adipose tissue characterized by increased energy expenditure, has emerged as an area of interest because manipulation of this tissue has potential to protect against diet-induced obesity by altering the balance of energy intake and consumption (1). The WT-1 mouse immortalized brown preadipocyte cell line is derived from primary brown preadipocytes. WT-1 preadipocytes can be induced to differentiate into brown adipocytes upon treatment with induction and differentiation factors. WT-1 cells express the brown fat differentiation factor BMP7 and brown fat marker uncoupling protein-1 (UCP1) (3) and are a valuable model for investigation into mitochondrial physiology during adipogenesis. The WT-1 cell line has been used to develop 3D assays for adipose tissue (4) and is well suited for a range of questions in cellular metabolic research. Source:WT-1 cell line was established from primary brown pre-adipocytes isolated from newborn mouse pups and immortalized with Simian virus 40 (SV40) large T antigen (2).Research Category:Stem Cell Research
Armazenamento : -140C Degree Freezer
Embalagem : 1X1EA