InSolution Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 – Calbiochem

REF : 124017-1MG
Marca : Sigma-Aldrich
Descrição :InSolution Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 - Calbiochem The InSolution Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Clique para mais informações
Categoria :
Descrição detalhada : A cell-permeable, potent, and selective inhibitor of Akt1/Akt2 activity (IC50 = 58 nM, 210 nM, and 2.12 microM for Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays). The inhibition is reported to be pleckstrin homology (PH) domain-dependent. It does not exhibit any inhibitory effect against PH domain-lacking Akts, or other closely related AGC family kinases, PKA, PKC, and SGK, even at concentrations as high as 50 microM. Overcomes Akt1/Akt2-mediated resistance to chemotherapeutics in tumor cells and is shown to block basal and stimulated phosphorylation/activation of Akt1/Akt2 both in cultured cells in vitro and in mice in vivo.
Sinónimos : InSolution Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 - Calbiochem
Fórmula molecula r: C34H29N7O
Armazenamento : -70C
Embalagem : 1X1MG