InSolution Casein Kinase I Inhibitor, D4476 – Calbiochem

REF : 218705-1MG
Marca : Sigma-Aldrich
Descrição :InSolution Casein Kinase I Inhibitor, D4476 - Calbiochem The InSolution Casein Kinase I Inhibitor, D4476 controls the biological activity of Casein Kinase I. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
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Descrição detalhada : A cell-permeable, potent, and relatively specific ATP-competitive inhibitor of CK1 (IC50 = 200 nM from S. pombe; 0.3 µM for CK1delta) and ALK5 (IC50 = 500 nM). A weak inhibitor of p38alpha MAP kinase (IC50 = 12 µM) and several other kinases tested, including PKB, SGK, and GSK-3beta. Suppresses the site-specific phosphorylation (Ser322 and Ser325) and nuclear exclusion of FOXO1A in H4IIE hepatoma cells. Shown to be ~10-fold more potent than IC261 (Cat. No. 400090; IC50 = 2.5 µM for CK1).
Sinónimos : InSolution Casein Kinase I Inhibitor, D4476 - Calbiochem
Fórmula molecula r: C23H18N4O3
Armazenamento : -20C
Embalagem : 1X1MG