EHNA, Hydrochloride – CAS 51350-19-7 – Calbiochem

Descrição detalhada : The racemic mixture of a cell-permeable adenine derivative that acts as a PDE II-selective phosphodiesterase inhibitor (IC50 = 0.8 and 2 µM against human and procine PDE II, respectively) and adenosine deaminase (Ki = 4 nM), while exhibiting little or much reduced potency toward PDE I/II/IV isozymes (IC50 >100 µM) of both human and porcine species. EHNA at 10 µM concentration is also reported to effectively and reversibly block the differentiation and maintain the pluripotency of hES (human embryonic stem) cell line SA121 in feeder-free cultures without exogenously added FGF for up to 30 passages in a manner independent of its known ADA and PDE inhibitory activities.
Sinónimos : EHNA, Hydrochloride - CAS 51350-19-7 - Calbiochem; erythro-9-(2-Hydroxy-3-nonyl)adenine, HCl
Fórmula molecula r: C14H23N5O · xHCl
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X10MG