NS-398 – CAS 123653-11-2 – Calbiochem

Descrição detalhada : A cell-permeable, selective inhibitor of cyclooxygenase-2 (COX-2) in vitro. Inhibits sheep placenta COX-2 (IC50 = 3.8 µM) while COX-1 activity is completely unaffected at concentrations up to 100 µM. Displays potent anti-inflammatory and analgesic activity in vivo in rat at concentrations of 0.3 to 5 mg/kg. Does not produce any significant gastrointestinal lesions even at single oral doses of 1000 mg/kg. A useful tool to explore the role of COX-2 in physiologic and pathophysiologic processes., A cell-permeable selective inhibitor of COX-2 in vitro. Inhibits sheep placental COX-2 (IC50 = 3.8 µM) while COX-1 activity is unaffected at concentrations up to 100 µM. Displays potent anti-inflammatory and analgesic activity in vivo in rat at concentrations from 0.3 to 5 mg/kg.
Sinónimos : NS-398 - CAS 123653-11-2 - Calbiochem; N-(2-Cyclohexyloxy-4-nitrophenyl)methanesulfonamide
Fórmula molecula r: C13H18N2O5S
Armazenamento : 10-30C
Embalagem : 1X5MG