GSK-3 Inhibitor X – CAS 740841-15-0 – Calbiochem

Descrição detalhada : An acetoxime analog of BIO, GSK-3 Inhibitor IX (Cat. No. 361550) that exhibits greater selectivity for GSK-3alpha/beta (IC50 = 10 nM) over Cdk5/p25, Cdk2/cyclin A, and Cdk1/cyclin B (IC50 = 2.4 µM, 4.3 µM, and 63 µM, respectively). A weak inhibitor of Cdk4/cyclin D1 and many other non-related kinases (IC50 >= 10 µM). Yields BIO (Cat. No. 361550) upon hydrolysis., An acetoxime analog of BIO, GSK-3 Inhibitor IX (Cat. No. 361550) that exhibits greater selectivity for GSK-3alpha/beta (IC50 = 10 nM) over Cdk5/p25, Cdk2/A and Cdk1/B (IC50 = 2.4 µM, 4.3 µM and 63 µM, respectively). Weakly affects the activities of Cdk4/D1 and many other kinases (IC50 >= 10 µM). Also acts as an aryl hydrocarbon receptor agonist in both yeast (EC50 >= 0.1 µM) and mammalian (EC50 = 0.16 µM) reporter systems.
Sinónimos : GSK-3 Inhibitor X - CAS 740841-15-0 - Calbiochem; (2?Z,3?E)-6-Bromoindirubin-3?-acetoxime, BIO-Acetoxime
Fórmula molecula r: C18H12BrN3O3
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X1MG