InSolution GSK-3 Inhibitor IX – CAS 667463-62-9 – Calbiochem

Descrição detalhada : A cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3alpha/beta (IC50 = 5 nM). Specificity was confirmed using various Cdk's (IC50 = 83 nM for Cdk5/p25, 300 nM for Cdk2/cyclin A, 320 nM for Cdk1/cyclin B, and 10 µM for Cdk4/cyclin D1), MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK (IC50 >= 10 µM). Inhibition of GSK by BIO has been shown to result in the activation of the Wnt signaling pathway and sustained pluripotency of human and murine embryonic stem cells (ESCs).
Sinónimos : InSolution GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem
Fórmula molecula r: C16H10BrN3O2
Armazenamento : 2-8C; 2-8C; 2-8C; 2-8C
Embalagem : 1X500UG