Hydroxyfasudil – CAS 155558-32-0 – Calbiochem

Descrição detalhada : A cell-permeable, hydroxylated metabolite of HA 1077 (Fasudil; Cat. No. 371970) that displays anti-anginal properties. Acts as an ATP-competitive and a reversible inhibitor of Rho-kinase (IC50 = 0.9 and 1.8 µM using a peptide and MLC as substrate, respectively) with ~100-fold greater selectivity over MLCK, MRCKbeta, and PKC. Reported to inhibit the Rho kinase-mediated contraction both in vitro and in vivo.
Sinónimos : Hydroxyfasudil - CAS 155558-32-0 - Calbiochem; ROCK Inhibitor XIV, 1-(1-Hydroxy-5-isoquinolinesulfonyl)homopiperazine, HCl, HA1100
Fórmula molecula r: C14H17N3O3S · xHCl
Armazenamento : -20C
Embalagem : 1X2MG