InSolution IKK-2 Inhibitor, SC-514 – Calbiochem

REF : 401485-1MG
Marca : Sigma-Aldrich
Descrição :InSolution IKK-2 Inhibitor, SC-514 - Calbiochem The InSolution IKK-2 Inhibitor, SC-514 controls the biological activity of IKK-2. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
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Descrição detalhada : A cell-permeable, potent, reversible, ATP-competitive and highly selective inhibitor of IKK-2 (IC50 ~3-12 µM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2) that also displays anti-inflammatory properties. Specificity has been reported using a panel of 31 additional kinases, including IKK isoforms IKK-1, IKK-i, and TBK-1 (IC50 >200 µM). Shown to specifically block NF-kappaB-dependent gene expression, but not MAP kinase pathways, in stimulated RASF synovial fibroblast cells. Does not inhibit the phosphorylation and activation of the IKK complex.
Sinónimos : InSolution IKK-2 Inhibitor, SC-514 - Calbiochem
Fórmula molecula r: C9H8N2OS2
Armazenamento : 2-8C; 2-8C; 2-8C; 2-8C
Embalagem : 1X1MG