JNK3 Inhibitor XII, SR-3576 – CAS 1164153-22-3 – Calbiochem

Descrição detalhada : A cell-permeable pyrazolourea compound that acts as a potent, ATP binding pocket-targeting, and JNK3-selective inhibitor (IC50 = 7 nM), inhibiting JNK1 only at much higher concentrations (IC50 = 170 nM) and exhibiting little activity against p38 even at concentrations as high as 20 µM. Shown to inhibit streptozotocin- (Cat. No. 572201) induced c-jun phosphorylation in INS-1 rat beta-pancreatic cells (IC50 = 1.3 µM)., A cell-permeable pyrazolourea compound that acts as a potent, ATP binding pocket-targeting, and JNK3-selective inhibitor (IC50 = 7 nM), inhibiting JNK1 only at much higher concentrations (IC50 = 170 nM) and exhibiting little activity against p38 even at concentrations as high as 20 µM. Shown to inhibit streptozotocin- (Cat. No. 572201) induced c-jun phosphorylation in INS-1 rat beta-pancreatic cells (IC50 = 1.3 µM).
Sinónimos : JNK3 Inhibitor XII, SR-3576 - CAS 1164153-22-3 - Calbiochem; 3-(4-(3-(3-Methylphenylureido))-1H-pyrazol-1-yl)-N-(3,4,5-trimethoxyphenyl)benzamide
Fórmula molecula r: C27H27N5O5
Armazenamento : 2-8C; 2-8C; 2-8C
Embalagem : 1X5MG